Antimicrobial activity of Rhus Coriaria L. and Salvia Urmiensis bunge against some food-borne pathogens and identification of active components using molecular networking and docking analyses

This research aimed to evaluate the in vitro antibacterial activity of methanol extracts Rhus coriaria L. (sumac) and Salvia urmiensis Bunge against some food-borne pathogens, survey phytochemical constituents extracts, their drug targets pathogens. The was evaluated six pathogens using agar well diffusion broth microdilution methods. Both exhibited highest obtained by sumac Staphylococcus aureus (27.7 ± 0.8 mm). minimum inhibitory concentration (MIC) bactericidal (MBC) tested bacteria were range 0.125-0.5 0.25-1 mg/mL, respectively. S. showed weaker antimicrobial with a MIC 2-4 mg/mL. A molecular networking analysis resulted annotation 18 12 compounds from respectively, which mainly related flavonoids. Molecular docking could effectively characterize glycosylated flavonoids high binding affinity studied enzymes. study confirmed efficacy as natural agents introduced wide compounds, can be used food preservation control foodborne food.